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日本腦炎에 對한 Cortisone의 效果

The Effect of Deltacortone on the Japanese B Encephalitis

최신의학 1960년 3권 11호 p.33 ~ 37
김덕진, 金庚湜, 車弘道,
소속 상세정보
김덕진 (  ) - 延世大學校 醫科大學 小兒科敎室
金庚湜 (  ) - 全北沃溝郡開井農村衛生硏究所
車弘道 (  ) - 延世大學校 醫科大學 小兒科敎室

Abstract


Studying the effect ,pf Deltacortone on Jap. B encephalitis, we selected seven severe cases, diagnosis of which was confirmed by the typical clinical symptoms, marked elevation of the H.I. test title for Jap. B encephalitis as compared with that of the early phase of the disease, and the other laboratory data. Deltacortone had been administered along with the general symptomatic treatment.
There was no noticeable change both in their fever and their symptoms for six to eight days after the administration of deltacortone in six of the seven cases. Two of them were dead one* to two weeks after the administration of the drug. In one case the fever did drop down to the normal level within 24 hours and the symptoms also became gradually normal. It is difficult to differentiate this dramatic effect from that of the natural healing course, which-is very common in the course of Jap. B encephalitis and is considered to be an accidental coincidence.
A follow up check of sequelae in the five surviving cases about one year after the onset of the diseas* e revealed that three of them had become normal, one ,of them had severe mental retardation and one of them had a spastic hemiplegia associated with moderate mental retardation. Judging from this result, we found that the cortisone is not effective for the treatment of Jap. B encephalitis but is rather presumed to be a contraindicative medication with the various other reasons evidenced by many other experimental studies.

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