잠시만 기다려 주세요. 로딩중입니다.

脾臟의 Allergy性變化에 미치는 各種 Steroid 物質의 影響에 關한 實驗的 硏究

Experimental Study on the Influence of Various Steroid Substances upon Allergic Changes in the Spleen

최신의학 1961년 4권 9호 p.45 ~ 77
윤해병,
소속 상세정보
윤해병 (  ) - 이화여자대학교 의과대학 내과학교실

Abstract


The endocrine effects upon the allergic reaction on different organs have been extensively investigated by a number of authors. The results were variable and sometimes conflicting in that the reactions were specific to each organ.
This investigation deals with a comparative histopathological study of the influence of various steroid substances upon the experimentally induced allergic inflammation with normal horse serum on the adult rabbit spleen. The steroids used were cortisone, cortical steroids produced by ACTI3. stimulation. estrogen -and androgen. These were given in two different doses, large and small (see text).
The results thereby obtained were distinct to each steroid, although these ´substances . were similar in basic. structure.´
Both cortisone and ACTH exerted pronounced inhibitory effects upon induced allergic inflammation of the rabbit spleen and the former showed greater inhibitory effect than the latter. The small doses of cortisone was more effective in suppressing the allergic reaction than the large doses, while reverse was true with ACTH.
Both estrogen and androgen showed significant enhancing effects upon the allergic inflammatory reaction, and the former produced more pronounced enhancing effect than the latter. Both of these were more effective with the large doses than with the small doses.

키워드

원문 및 링크아웃 정보

등재저널 정보