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抗結核劑投與가 骨修復機轉에 미치는 影響에 關한 實驗的 硏究

Experimental Study on the Influence of Antituberculous Drugs to the Reparative Osteogenesis

최신의학 1962년 5권 5호 p.97 ~ 110
노약우,
소속 상세정보
노약우 (  ) - 서울대학교 의과대학 해부학교실

Abstract


The phosphorus metabolism in artificially injured tibia of rabbits and the influences of antituberculous drugs on reparative osteogenesis were experimentally studied using radioactive phosphorus P32 as a tracer.
Sixty-eight normal rabbits were, under aseptic conditions, subjected to the fractures by imposing the 3 mm wide and 6 mm long defects on the cortex of the left tibia. These animals were divided into; 20 control, 27 SM(25 mg/kg), and 21 INH(20 mg/kg) groups to which 100,tC of P32 with the form of Na H2 P32 04 solution were intravenously given 48 hours prior to experiment.
The data were obtained with direct counting method, macroautoradiography and ashing method. The followings were the results:
1. On the first day of operation, the P32-uptake, i. e. the phosphorus metabolism was more inactive in fracture site than in the normal. The metabolic rate was the lowest in the control and lower in the INH group.
2. So-called unstable stage lasted 3 or 4 days after the operation and there were no marked P32 -uptake difference between the fracture and normal site in this period.
3. After fifth day of the fracture, the affected site showed the marked P32 -uptake than the normal, which indicates the more active osteogenesis. In both groups given antituberculous drugs the osteogenesis took place not only earlier but more actively than in the control. On this, the INH group showed the more active phosphorus metabolism than the SM group.
4. During the period from the tenth to fifteenth day after the fracture, the operated site showed the daily increase of P32 -uptake. INH-and SM-groups showed the more active osteogenesis than the control.
5. In three weeks after operation the P32 -uptake had reached its speak in all experimental groups. The count ratio of -the fracture and normal sites had reached 2.5 in the control-and SM-groups, while was 2.6 in the INH group.
6. After four weeks of the operation the P32 -uptake curve showed a decline which was more rapid in the SM and INH-groups. A relative slow decline of the curve was observed in the control.
7. In fifth week of the fracture the P3 -uptake curve of the SM group showed as much decline as the count ratios reacthed to 1.3. The count ratios in the INH and control-groups were 1.8 and 1.7 respectively which suggests the progress of relatively active phophorus metabolism.
8. Even after seventh week of the fracture the continuation of osteogenesis though insignificant was observed in all experimental groups.

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