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허파속 및 배속 양성 압력이 조직 수분량 및 혈장량에 미치는 영향

Plasma volume and tissue water content changes in rabbits under positive intrapulmonic and intrabdominal pressure.

최신의학 1963년 6권 6호 p.73 ~ 81
권기택,
소속 상세정보
권기택 (  ) - 서울대학교 의과대학 생리학교실

Abstract


Circulating plasma volume and tissue water content changes were observed in 55 nembutalized rabbits under positive intrabdominal pressure(18 mmHg), positive intrapulmonic pressure(9 mmHg), and positive intrabdominal and intrapulmonic pressure combined. The control group consisted of 20 rabbits, positive intrabdominal pressure group 16 positive intrapulmonic pressure group 9, and combined intrabdominal and intrapulmonic pressure group 10 rabbits.
Tissue water contents were measured in plasma, liver, small intestine, and gastrocnemius muscle by drying at 105C. Extracellular water space was measured by means of SCN dilution method. Plasma volume was measured by means of T-1824 dilution. The following data were obtained.
1. Under positive pressure there appeared hemoconcentration, namely, decrease in plasma volume and plasma water content and increase in hematocrit value.
2. The hemoconcentration indices were 0.086 in the normal control group, 0.109 in the combined intrapulmonic and intrabdominal positive pressure group, 0.119 in positive intrabdominal pressure group, and 0.123 in positive intrapulmonic pressure group. The increasing order of hemoconcentration index showed the increased degree of hemoconcentration..
3. Tissue water content increased in liver, small intestine and gastrocnemius muscle. Positive intrapulmonic pressure group showed the greatest increase and combined positive pressure group showed the least increase. Tissue water content increase under positive intrabdominal pressure was between these two extremes.
4. Extracellular water increased in liver and gastrocnemius muscle. In these tissues the increase in the total tissue water resulted from the increase in extracellular water content. As an exception extracellular water content of liver under positive intrabdominal pressure decreased.
5. In the small intestine extracellular water content decreased under all 3 experimental conditions. The increase in tissue tension was assumed to be the cause of the decrease in small intestine extracellular water.
6. Transfer of water across capillary membrane and cell membrane proper was discussed.

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