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Cortisone 및 Vitamin이 骨折治癒에 미치는 影響에 關한 硏究

The Experimental Studies of the Influences of Cortisone and Vitamins on the Fracture Healing

최신의학 1965년 8권 1호 p.93 ~ 98
김대영,
소속 상세정보
김대영 (  ) - 서울대학교 치과대학 구강해부학교실 서울대학교 의과대학 방사성동위원소진료실

Abstract


The Experimental Studies of the Influences of Cortisone and Vitamins on the Fracture Healing
Report 3. An Experimental Study of the Influences of Vitamin A and Cyanocobalamin on the Fracture Healing.
Dae Young Kim, D. D. S.
College of Dentistry, Seoul National University
The influences of Vitamin A and cyanocobalamin on the mucopolysaccharide and sulfuric acid which play the important roles in the fracture healing were studied in the rats. Thirty mature healthy rats were divided into 3 groups, 10 in each. The first group was the control animals to which 0.2 ㎖ of physiological saline was intramusculary given at the 3 days intervals for 21 days. The second group received 30㎎ of Vitamin A, and the third, 15 ㎍ of cyanocobalamin instead of the saline. S^(35) was subcutaneously given to each group 24 hours before the sacrifice in the same doses dated in the Report 1. The distribution of S^(35) and the histopathological changes were studied with the macro-, and microautoradiography in accordance with the special metachromic staffing with toluidine-blue and eosin.
Following were the results:
1. Vitamin A induced an increase of S^(35) uptake in the growing portions of the bones and fracture sites.
2. In the Vitamin A treated animals, a clear halous blackening with the metachromic appearance was present in the chondroid matrix which was surrounded by an irregular fibrous bundle.
3. In the cyanocobalamin treated animals, a large amount of chondroblasts appeared in the healing sites and the S^(35) uptake was also active, however, the osteoblasts were not observed.
4. Vitamin A and cyanocobalamin enhanced the differentiation of the chondrocytes in the fracture sites, epi- and diaphyses and also formed an excess sulfated mucopolysaccharide complex in the fracture sites.

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