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암토끼에 있어서 임신 및 성호르몬 작용하의 체액의 변동

Body Water Changes Under Influences of Ovarian Hormones and pregnancy in Females Rabbits.

최신의학 1965년 8권 2호 p.85 ~ 94
김영택,
소속 상세정보
김영택 (  ) - 서울대학교 의과대학 생리학교실

Abstract


Tissue water contents, SCN space and tissue electrolyte changes were observed in 56 female rabbits. Animals were divided into 5 groups. The control group consisted of 18 ovariectomized rabbits, estrogen(the second) group consisted of 10 animals ovariectomized and administered with estrogen 25 ㎍/㎏ daily for 7 days. In the third estrogen plus progesterone group consisting of 10 ovariectomized, animals daily dose of 0.5 ㎎/㎏ progesterone was administered for 5 days after 7 days of estrogen. The fourth group was natural pregnancy group of 10 rabbits. The fifth was natural estrusgroup of 8 rabbits.
Tissue water contents and tissue electrolytes were measured in uterus, liver, small intestine and gastrocnemius muscle by drying at 105 C and flamephotometry. The extracellular water space was measured in total body, uterus, liver, small intestine, spleen and gastrocnemius muscle by means of SCN dilution method. The following data were observed.
1. Uterine tissue water contents were increased in all experimental groups as compared to the control group. The extracellular water, however, decreased in all experimental groups. Thus the increase in the intracellular water was the origin of total tissue water increase.
2. Sodium and potassium concentration in the uterine tissue showed a marked increase in all experimental groups. The behavior of electrolytes and water content changed in parallel in general.
3. Tissue water contents of liver showed increases in the second and third groups. The extracellular grater of liver decreased in all groups. Subsequently in these two groups there was a marked increase in the intracellular water. In the pregnancy and estrus groups no variation of tissue water content was observed. It was concluded that the i ntracellular water increased in these two groups. Sodium and Piptassium of liver tissue increased in all groups.
4. In small intestine, tissue water content decreased in pregnancy and estrus groups accompanied by no change in the extracellular water. Accordingly in these two groups there was a decrease in the intracellular water. Sodium and potassium concentration in these two groups decreased also.
5. Skeletal gastrocnemius muscle was not affected in water or electrolyte concentration in all groups. As an exception, in pregnancy group there was a decrease in potassium concentration.
6. Spleen tissue in general showed a decrease in tissue water content.
7. Total body SCN space increased in the third and estrus group.
8. Ovarian hormone susceptibility in inducing tissue water changes was greatest in uterus and decreased in the order of liver, spleen and small intestine.Skeletal muscle was not the target organ of ovarian hormones.
9. Total body water of rabbit fetus was 83.0% body weight.

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