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폐결핵치료제로서 DATC의 가치

"DATC" in the Treatment of Pulmonary Tuberculosis

최신의학 1966년 9권 11호 p.26 ~ 29
이찬세, 하두철,
소속 상세정보
이찬세 (  ) - 가톨릭의과대학 내과
하두철 (  ) - 가톨릭의과대학 내과

Abstract


1) DATC (Isoxyl) (4-4´ DiisoamyIoxythiocarbanUide) has been tried on 50 cases of chronic resistant pulmonary tuberculosis patients to check the clinical significance.
This was given in dose of t1.01.5 gm bid together with INH 200 mg bid for 5 months or more.
2) Bacteriological negative conversion of sputum occurred in about 27% and the marked X-ray improvement attained in about 10% and there was no remarkable side effect noted.
3) This was far superior in it´s effectiveness and muchsafer to compare with author´s own previous experience of DETC(Esoxyl, Tiberon)(4-4´ Diethoxylthiocarbanilide).
4) The author inclined to assume that DATC could be used as one of secondary drugs in the treatment of chronic pulmonary tuberculosis same as 1314th or pyrazinamide.
However the author could not be clarified on the possibility of replacing PAS with DATC in primary chemotherapy cases for former´s frequent side effects.

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