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고려인삼이 더위에 폭로된 흰쥐의 부신 아스코르빈산에 미치는 영향

Effect of Panax Ginseng on the Adrenal Acid Content of Rats Exposed to Heat

최신의학 1967년 10권 3호 p.73 ~ 77
許創龍, 金正鎭, 金宗圭,
소속 상세정보
許創龍 (  ) - 가톨릭대학 의학부 생리학교실
金正鎭 (  ) - 가톨릭대학 의학부 생리학교실
金宗圭 (  ) - 가톨릭대학 의학부 생리학교실

Abstract


This study was planned to see whether the Nnax Ginseng has any influence upon the stress mechani3f i- iii fats- exposed to high ieii peratiir`e:
Dividing 90 male albino rats whose body weight ranged from 150 to 200 gram into saline :group and ginseng - group and utilizing the adrenal ascorbic acid content as an indicator; of reaction to stress, experiments were carried out as follows
For 10 consecutive days the ginseng group and the saline group received each day 0.5 ml per 100 gram body weight of ginseng extract and physiological saline, respectively:. On the 5th day after beginning of _ginseng or saline administration the left adrenal ascorbic acid content - of all rats. was measured
i and regarded as control. value of,.. adrenal ascorbic acid ´content:, before. stress; Beginning.on the 8th experimental day, _both the. ginseng and- the saline grbups were exposed ,to heat (in.a warm-chamber of 350, for one: hour every day for 3..conseutive days. The right adrenal ascorbic acid content was measured immediately; z. hours after; or 5 _hours after termination of the last heat stress. .
The ascorbic; acid was - measured:- colorimetrically with Coleman : Junior S.peetrophotometer . utilizing the´ reduction of 2; 6-dichlorophenol=indophenol sodium. To prepare ginseng extract, 300 gram of Korean Panax Ginseng was extracted with 95 yo ethyl alcohol on a boiling´ water , bath fbr.. abotit 300 -hours. This procedure yielded 54 gram of dark brown substance from which a ginseng extract was prepared´ dissolving r. 4 mg of the substance in 1 ml of physiological saline.
Results obtained were as follows:
1) Ginseng extract had no influence upoi} the adrenal ascorbic acid `content of rats before exposure to heat stress.
2) The adrenal ascorbic acid content of ginseng group decreased significantly over that of saline group innmediately, or 2 hours after termination´ of one hour heat stfess. However, measurement at 5 hours ` after termination of heat stress Aowed that adrenai ascorbic acid content of ginseng :group tended to regain normal value, whereas that of the saline group continued to decrease, the difference between two values being significant. ´
Judging. from the, above results, it is concluded that the administration of ginseng facilitates the reaction to and accelerates the recovery from the heat stress.

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