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循環血液量 增減에 따른 有效酸素量의 變動

Changes of Available Oxygen by Increase and Decrease of the Circulating Blood Volume

최신의학 1968년 11권 7호 p.89 ~ 96
전렬경,
소속 상세정보
전렬경 (  ) - 경북대학교 의과대학 생리학교실

Abstract


Changes of the available oxygen by increase and decrease of the circulating blood volume were studied i n 25 mongrel dogs. In this study, the dogs were divided into five groups, namely group I, group 11, group 111, group IV and group V. In group 1, an amount of blood one third of the circulating blood volume was bled from the femoral artery. In group 11 an amount of blood one third of the circulating blood volume was bled after ligation of the splenic vessels. In group 111, an amount of blood one third of the cifeulating blood volume was bled and retransfused an amount of blood equal to shed blood through jugular veil 60 minutes after blood shedding. In group IV, an amont of blood one third of the circulating blood volume was bled and an amount of Dextran equal 0 shed blood was infused through jugular vein 60 minutes after blood shedding. In group V, an amount of blood one third of the circulating blood volume was transfused without blood shedding. In all groups, available oxygen, cardiac output, hemoglobin concentration, 02 saturation, 02 consumption and minute ventilation were measured before and after blood shedding in groups I and 11, before blood shedding and after re-transfusion in group 111, before blood shedding and after Dextran infusion in group 1V, and after whole blood transfusion in group V.
The results obtained were summarized as follows:
?) :´_vailable oxygen was significantly decreased to approximately 33 Yo of the control side in group i and to approximately 18% of the control side in group II over that of the group I, but no significant change was noted following re-transfusion in group 111, whereas it was remarkably decreased to approximately of the control side following Dextran infusion in group IV. In group V. it was increased significantly.
2) Cardiac output was remarkably decreased to approximately 45% of the control side in group I and to approximately 250/6 of the control side in group 11 over that of the group 1, but in group Ill it was not significantly changed. In groups IV and V, it showed tendency to increase but no significant change.
3) Hemoglobin concentration was markedly decreased in group I and 11, more prominent in group 11 but no significant change was seen in group 111, whereas in group 1V, it was remarkably decreased to approximately 630/ of control side following Dextran infusion. In group V, it was increased significantly.

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