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Changes in Respiration and Arterial Pressure immediately after the Intravenous Administration of Thiopental in Dogs.

ֽ 1969 12 1ȣ p.79 ~ 83
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In despite of that thiobarbiturate is well known general anesthetics, the effect of the drug on the arterial pressure is not well clarified yet. The thiobarbiturate has direct constricting effect on arterial smooth muscle and has reducing action on the contractility of the myocardium. Therefore, it can raise arterial pressure in one hand and can decrease the pressure on the other hand.
The present study is attempted to further elucidate the effect of rapidly administered thiopental of comparatively small dosage on the change in arterial pressure and respiratory depression immediately after the administration.
Sodium thiopental was administered in does and rate of 2mg,/kg/sec. through femoral vein of experimental dog with was prior anesthetized lightly by 10 mg/kg of 2.50/, thiopental. The respiration and femoral arterial pressure were monitored through out the experiment and heart rate and arterial pH were measured before and after the administraion of the drug.
The results abtained are summarized as follows:
1. Respiration was depressed pronouncely about 20 seconds after the administration of thiopental and temporary apnea was developed in about 60% of the observations. Recovery of the respiration to the control state was achieved about 20 minutes after the administration. Arterial blood pH was lowered in degree of about 1.2 by the thiopental induced respiratory depression.
2. Decrease in arterial pressure became observable 14 seconds after the administration and at 30 seconds after the thiopental, arterial pressure showed peak decrease of about 27 mmHg. Lowered pressure by thiopental recovered to control level after about 50 seconds of the administration. In about 62% of.the observation, the change of arterial pressure was biphasic, initial short rise and decrease there-after. The average degree and duration of initial rise in arterial pressure were about 18 mmHg and 4 seconds. The heart rate decreased to 90% of control rate after 1 minute of the administration of thiopental.