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韓國人 姙娠中毒症患者에 있어서의 腎機能과 電解質 및 窒素, 燐代謝에 關한 硏究

A Study on the Renal Function and Metabolism of Electrolytes, Nitrogen and Phosphorus in Toxemia of Pregnancy

최신의학 1969년 12권 7호 p.37 ~ 47
김동구,
소속 상세정보
김동구 (  ) - 서울대학교 의과대학 산부인과학교실 및 소아과학교실

Abstract


This study was directed to obtain the glomerular filtration rate in toxemia of pregnancy by the method of endogenous creatinine clearance and the relation with its clinical symptoms.
The material was obtained from 49 toxemic pregnant women in the ward and outpatient clinics, Dept. of Ob. & Gyne., S. N. U. H., who visited with complaints of albuminuria, edema and hypertension, and from 30 normal control group.
Quantitative calculation of serum and urine creatinine was performed by the standard method of clinical chemistry reported in Academic Press.
All analysis were performed in duplication. The results were as follows;
1. Between control group and mild cases of toxemic pregnant women, each mean of urinary creatinine excretion, serum creatinine concentration, and endogenous creatinine clearance was not considerably different. In severe cases group of toxemic pregnant women, however, serum creatinine concentration raised significantly more than control group and mild cases group of toxemic pregnant women, and endogenous creatinine clearance dropped considerably, and also it was observed that glomerular filtration rate was proportionally decreased according to the severity of toxemia.
2. In toxemia group, there seems to be no relation between urinary creatinine excretion and serum creatinine concentration.
3. In severe cases, dropping of endogenous creatinine clearance tends to lead slightly to decrease of creatinine excretion.
4. Retention of serum creatinine concentration appears to lead to decline of endogenous creatinine clearance. Hyperbolic relationship between them was observed.
5. The comparison of creatinine clearance of severe cases group of toxemic pregnant women with its clinical symptomatology may be worthwhile to point out as follows;
I. There is no relation between blood pressure and endogenous creatinine clearance.
II. Severity of edema correlates to degree of a decline of endogenous creatinine clearance.
III. Endogenous creatinine clearance is proportionally decreased according to the severity of proteinuria.

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