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한국인 정상수액의 Immune Globulin치의 정량에 관한 연구

Quantitation of Immune Globulin Level of Normal Cerebrospinal Fluid in Korean

최신의학 1970년 13권 1호 p.56 ~ 62
최덕영, 임수덕, 심보성,
소속 상세정보
최덕영 (  ) - 서울대학교 의과대학 신경외과학교실
임수덕 (  ) - 서울대학교 의과대학 신경외과학교실
심보성 (  ) - 서울대학교 의과대학 신경외과학교실

Abstract


With development of immunochemical methods for analysis of proteins in cerebrospinal fluid, quantitative determination of immune globulin level in cerebrospinal fluid and it´s purification have been made possible in recent years.
In 1942, Kabat and co-workers iu> , using the Tiselius 22) electrophoresis method, first reported that the cerebrospinal fluid gamma-globulin content was elevated in some patients with multiple sclerosis and s neurosyphilis.
A method of electroimmunodiffusion (RID) suitable for use with minute volumes of unconcentrated cerebrospinal fluid or other body fluid was described by Merill, et al.´s), in 1967.
The purpose of this study is to quantitate the immune globulin level of normal cerebrospinal fluid in Korean, by the method of RID.
The results are as follows: The IgG level of normal cerebrospinal fluid in Korean was 2.48+0.12 mg/ 100ml, the IgA level, 0. 27±0. 01 mg/100ml, and the mean ratio of IgG to total protein of normal cerebrospinal fluid was 6.9%.

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