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生後齡의 增加가 正常白色마우스의 膵臟細胞更新系에 미치는 影響에 關한 自記放射法的 硏究

Cell Renewals and Aging Effects on Pancreas of Mouse

최신의학 1970년 13권 12호 p.67 ~ 78
성노준,
소속 상세정보
성노준 (  ) - 서울대학교 의과대학 해부학교실

Abstract


The effects of different postnatal ages on the exocrine and endocrine portions of the pancreas from the normal albino mice have been studied by means of microradioautography after the intraabdominal administration of single dose of 0.8 microcurie of tritiated thymidine per gram of body weight of the animal.
Two groups of the animal, namely 29 suckling young and 39 adult, were put into six age groups. The age range was from 4-day to more than 50 weeks of the postnatal age.
The microradioautogram were exposed 28´ days in room temperature, were stained with Ehrlich´s acid hematoxylin after the processing of the filmed slides.
1. Fairly high labeled nuclei were observable in the sections from the suckling young animal tissues. In the adult, however, it seems to be that the decrease of the cell renewal rates was accompanied with the increase of the postnatal age. Especially, relatively high renewal rate from the estrus stage of the young adult female was contrasted with that of the low one from old adult estrus female group. Beside above, the ratio between cliestrus and estrus groups of the young adult female was reversed in that of the old adult female group.
2. On the contrary the cell renewing of the endocrine cell appears to be increase, while the increase of the postnatal age in the adult. In the adult female, the ratios of the estrus and diestrus stages between the young and old adult females were exactly followed same tendencies with those of the exocrine portion of the adult female groups.
3. A peculiar low labeling was noted on the endocrine cell renewing of the 3-week old suckling young in both the sexes for present experiment.

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