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Skin sensitization test of potassium hydroxide in guinea pigs

예방수의학회지 2020년 44권 4호 p.169 ~ 173
Hwang Du-Hyeon, 김석, 김의경, 이후장,
소속 상세정보
 ( Hwang Du-Hyeon ) - Gyeongsang National University College of Veterinary Medicine Institute of Animal Medicine
김석 ( Kim Suk ) - Gyeongsang National University College of Veterinary Medicine Institute of Animal Medicine
김의경 ( Kim Eui-Kyung ) - Gyeongsang National University College of Veterinary Medicine Institute of Animal Medicine
이후장 ( Lee Hu-Jang ) - Gyeongsang National University College of Veterinary Medicine Institute of Animal Medicine

Abstract


This study was to evaluate the skin sensitization of potassium hydroxide (KOH) by the guinea pig maximization test. In the preliminary test, the induction and challenge dose of KOH were determined as 1.0 and 0.2%, respectively. Guinea pigs were sensitized with intradermal injection of 0.1ml KOH for 24 h. After 1 week, 1.0% of KOH was treated on the site of injection and 0.2% of KOH was challenged 2 weeks later. The average skin reaction evaluated by erythema and edema on the challenge sites and sensitization rate in the KOH-treatment group at 24 h were 0.0 and 0%, respectively, which are substantially low compared with in the 2,4-dinitrochlorobenzene-treatment group (positive control group) (average skin reaction: 3.0, sensitization rate: 100%) and identical with in the distilled water-treatment group (negative control group), representing a weak sensitizing potential. The average skin reaction and sensitization rate observed at 48 h were 0.0 and 0% in the KOH-treatment group, respectively, and 2.0 and 100% in the positive control group, respectively. It was concluded that 1.0% of KOH classified to Grade I, induced no sensitization when tested in guinea pigs.

키워드

Potassium hydroxide; skin sensitization; guinea pigs

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