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Cytotoxicity evaluation of different commercially available absorbent feminine hygiene products and a transdermal patch using direct contact and extract exposure methods

예방수의학회지 2020년 44권 4호 p.201 ~ 206
Reyes Alisha Wehdnesday Bernardo, Huy Tran Xuan Ngoc, Vu Son Hai, Nguyen Trang Thi, 민원기, 이후장, 김석,
소속 상세정보
 ( Reyes Alisha Wehdnesday Bernardo ) - Gyeongsang National University College of Veterinary Medicine Institute of Animal Medicine
 ( Huy Tran Xuan Ngoc ) - Gyeongsang National University College of Veterinary Medicine Institute of Animal Medicine
 ( Vu Son Hai ) - Gyeongsang National University College of Veterinary Medicine Institute of Animal Medicine
 ( Nguyen Trang Thi ) - Gyeongsang National University College of Veterinary Medicine Institute of Animal Medicine
민원기 ( Min Won-Gi ) - Gyeongsang National University College of Veterinary Medicine Institute of Animal Medicine
이후장 ( Lee Hu-Jang ) - Gyeongsang National University College of Veterinary Medicine Institute of Animal Medicine
김석 ( Kim Suk ) - Gyeongsang National University College of Veterinary Medicine Institute of Animal Medicine

Abstract


We investigated the cytotoxic potential of three different commercially available absorbent feminine hygiene products and one transdermal patch using direct contact and extract exposure methods. Two different cell lines were used ? mouse fibroblast L929 and normal human skin fibroblast CCD-986sk cell lines. The test samples were extracted using three different methods in accordance to International Organization for Standardization (ISO). Viability of cells was analyzed using MTT assay and morphology of the cells were also observed using phase contrast microscopy. Overall, the direct contact method using L929 cells showed that all the test samples had no toxic effect when exposed to extracts for 1 h. For the exposure method, no toxic effect was observed in both L929 and CCD986sk cells incubated with all the test samples regardless of the extraction methods used.

키워드

CCD-986Sk; cytotoxicity; L929; sanitary pad; transdermal patch

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