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乳幼期의 蛋白質不足이 腦 및 其他器官의 發達에 미치는 影響

Influence of early protein undernutrition on the size and composition of the rat brain and other organs

한국영양학회지 1970년 3권 2호 p.81 ~ 85
劉貞烈, 辛正來,
소속 상세정보
劉貞烈 (  ) - 德成女子大學校 營養學科
辛正來 (  ) - 서울特別市衛生試驗所

Abstract


These experiments were designed to study the influence of protein undernutrition during lactation period(3 wks) or after-weaning period(8 wks) on growth of organs, and on brain and liver composition of the experimental rats. The following experimental groups were studied.
Group No. Rats Lactation Period(3 wks) After-weaning Rehabilitation Period
(Diet of mother rat) period(8wks) (17wks)
I 8 25% Casein diet 25% Casein diet 25% Casein diet
1 8 1256 Casein diet 250´ Casein diet 25% Casein diet
11 8 255?ol Casein diet b,o Casein diet 230´ Casein diet
N 8 12% Casein diet 5b Casein diet 25.´16 Casein diet
After the pe,-riod of rehabilitation(17 wks) with 25´o casein diet, the following results were obtained
1. Most of the organs except the spleen could not catch up w;th the normal group in their weights for the group of protein undernut7ition during lactation(, -,ks . even after 17%reeks of rehabilitation. For the group of protein undernutrition during after-weaning period(8 wks) brain, lung, heart, spleen and pancreas could catch up with the normal group after rehabilitation. According to this result it is assumed that the growth of brain, lung. heart and pancreas might be developed mostly during lactation period and that the growth of liver and kidney- might be developed iterweaning period continuously.
2. For the groups of protein underuntrition during lactation period or after-weaning period the amounts of total lipid, cholesterol and phospholipid of brain were lower than those of normal group. Especially, cholesterol level was significantly lower than normal group. And there was also a significant difference in the phospholipid level of the after-weaning(8 wks) deprivation group.
3. The groups of protein undernutr ition during lactation or after-weaning period(8 wks) showed lower level of liver nitrogen and higher level of liver fat. Especially, protein undernutrition during lactation gave a greater influence on the level of liver fat.

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