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韓國人을 對象으로 한 異常血色素의 變異型에 關한 硏究

Hemoglobin variant Found in Koreans

한국영양학회지 1970년 3권 3호 p.161 ~ 166
노일협,
소속 상세정보
노일협 (  ) - 숙명여자대학교 약학연구소

Abstract


One male in the former group of 2110 Korean males of the Republic of` Korea Army stationed Taegu. And two males and one female in the later group of 4590 Korean school children and university students in Seoul and Taejuon were found to have a slow hemoglobin in addition to normal hemoglobin A.
In all four subjects the slow component migrated at a rate characteristic of the G hemoglobin. The overall incidence of the variant in the present group of Koreans was low: 4 in 6700 or 0.06 per cent.
It appears significant that no insitance of hemoglobin E were found among these Korean subjects. Hemoglobin E has been found among numerous ethnic groups of Southeast Asia and the variant most frequently appeared in Chinese subject.
By Urea-Starch-Gel Electrophoresis in Alkaline PH and A.I. Chernoff method was demonstrated that another 3 cases of abnormal hemoglobin also were beta-chain variants. This was reconfed by Hybridization Experiment with canine hemoglobin.
And the results of family test of 3 case of abnormal hemoglobin were heterozygous carrier.

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