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肝膽道 疾患에 있어서의 血淸 Transaminase 活性度 및 其 經過에 따르는 活性値 變化의 追求觀察

SGO-TRANSAMIMASE SGP-TRANSAMINASE ACTIVITES, AND FOLLOW-UP DETERMINATIONS OF THF ENZYMES IN HEPATOBILIARY DISEASES

항공의학 1963년 11권 1호 p.43 ~ 68
곽낙오,
소속 상세정보
곽낙오 (  ) - 서울대학교 대학원 의학과 내과학전공

Abstract


Since the value of determination of transammase in clinical fields was introduced, number of papers on the SGOT & SGPT activites in hepatobiliary, disease were reported.
The author has measured the activities serum, glutamic osalacetic transaminase and serum glutamic pyruvic transaminase and serum glutamic pyruvic transaminase´ according to the sigma Frankel mgthod with´ the following ~.case3 admitted and visited to our´clinic:126 cases of liver cirrhosis, 13cases of .liver cirrhosis,. with canner,, 11 cases of liver cancer,, 19 cases of acute hepatitis and 19 cases of chronic hepatitis, 2 cases of serum hepatitis, 2 cases of liverabscess, abscess, 13 cases of cholelithiasis, 6 cases of clonorchiasis sinensis, 6 cases of others and 28casesof normal subjects as control.
The activities of SGOT : and SGPT in liver cirrhosis was discussed"separately, in early, °nioderately advanced, and for .advanced ´liver cirrhosis devidea by clinical and laboratory findings. Also, in hepatitis the SGOT & SGPT activities were determined in four groups to find out the varies of the enzymes due to duration of jaundice.
Author discussed the correlation of transam:inane activities with liver- function tests and serial checks. of the enzyme activites following the course were performed in this paper on --the hepatobiliary diseases, whereover, the val.ue of SGPT to SGOT ratio was discussed to see the variety of this enzymes.
The results were summarized as follows.
1) -The SGOT and SGPT activities in hepatobiliary diseases and normal subjects are shown in table 1.
The highest activities. of SGOT, and SGPT. -were- 740 units/ml, and 300 units/ml in liver cirrhosis, 1800 units/ml and. 1900´ units/ml in .acute hepatitis respectively.
2) In liver cirrhosis 22.2 % of 126 casess tested showed.´ the activities of SGOT; within normal limits, ..and generally, the SGOT. and SG PT activitites in hepatitis _showed´ relatively ;high value to other cases as shown in table lb and fig I.
3) The SGOT and SGPT activities did not reflect the liver functon tests, but the´ SGOT activities were increased with the increase of serum total bilirubin, the SGOT and SGPT activities were increased with the elevation of thymol turbidity and cephaline cholesterol flocculation test in liver cirrhosis and chronic hepatitis correspondingly.
4} In follow-up determinations of SGOT and SGPT activates the results were showed decrease of SGOT and SGPT activities in improving cases increase of SGOT and SGPT activities in progressively ´aggravated cases and - no, changes of SGOT & SGPT activites in the cases with station.ary course.
5) SGOT activities in the cases with chronic liver diseases and SGOT especi ally SGPT activities in the cases with acute liver disease were sensititive to reflect the course.
6) Transaminase activities were figher in the cholelithiasis with jaundice than that of nonjaundiced and this activities of enzymes returned to ´ the , normal limits with the disappearance of jaundice.

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