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급성 및 만성 저산소증이 Fatty Acid Synthase와 ATP-citrate Lyase 효소의 양적 변화에 미치는 영향

The Effects of Acute and Chronic Hypoxia on the Induction of Fatty Acid Synthase and ATP- citrate Lyase

항공의학 1992년 40권 1호 p.43 ~ 59
김경섭, 이인기,
소속 상세정보
김경섭 ( Kim Kyung-Sup ) - 항공의학적성훈련원
이인기 ( Lee In-Kee ) - 항공의학적성훈련원

Abstract


The. biosynthesis of lipogenic enzymes in the liver is regulated by dietary control. In present study, we intended to observe the effects of hypoxia on the induction of fatty acid synthase, ATP-citrate lyase, and glucose-6 phosphate+ dehydrogenase. The synthesis of these three enzymes was induced in rat liver by refeeding a high-carbohydrate
diet after starvation for 36 hours. The inductions of these enzyme were abolished by acute hypoxia at 10 hour after refeeding, suggesting that acute hypoxia probably increased the, concentration of the induction of these lipogenic enzymes in the rats ´which adapted to the hypoxia for 30 days. It is thought that the elevated state of the glucocorticoid by adaptation to hypoxia seems to partially contributed to the prorotective effect on the . induction of the lipogenic enzymes from inhibition by hypoxia, although the other complex regulatory mechanisms probably are present.

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