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반응성 산소 대사물에 의한 지질과산화에 Harmaline과 Harmalol의 효과

Effect of Harmaline and Harmolol on Lipid Peroxidation by Reactive Oxygen Species

항공의학 1992년 40권 1호 p.123 ~ 143
신용규, 강호만, 이무훈,
소속 상세정보
신용규 ( Sin Young-Kyoo ) - 항공의학적성훈련원
강호만 ( Kang Ho-Man ) - 항공의학적성훈련원
이무훈 ( Lee Moo-Hoon ) - 항공의학적성훈련원

Abstract


Iron is a reactive metal ion which is known to catalyze damages of cellular macromolecules caused by oxygen radicals and it´s reduction may play a major role in lipid peroxidation. The iron-catalyzed Haber-Weiss reaction to produce hydroxyl radical is catalyzed by iron and hydroxyl radical appear to participate as an initiator of lipid peroxidation.
Therefore in the present study effect of harmaline and harmalol were studied with respect to generation of oxygen radical during oxidation or reduction of iron in relation to the lipid peroxidation of microsome of rat liver caused by iron.
Lipid peroxidation. of microsome by Fe++ and H202 were inhibited by hydrogen peroxide scavenger such as catalase, hydroxyl radical scavenger such as DMSO sodium formate and histidine, sing let oxygen scavenger such as DABCO . Harmaline and harmalol inhibited hydroxyl radical generation and singlet oxygen formation but not inhibited superoxide generation Antioxidant of harmaline and harmalol on lipid peroxidation is suggested by hydroxyl radical and siglet oxygen scavenging effect.

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