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Ehrlich 腹水癌 移植에서 일어나는 壤死의 宿主防禦反應과의 關係

The Significance of the Necrosis Appearing in Implanted Ehrlich Carcinoma Growth

현대의학 1968년 9권 4호 p.473 ~ 478
徐鐸煥, 金永濟,
소속 상세정보
徐鐸煥 (  ) - 가톨릭大學 醫學部 病理學敎室
金永濟 (  ) - 가톨릭大學 醫學部 病理學敎室

Abstract


It is generally accepted that Ehrlich carcinoma is not strain specific and it has lost its lowing tre8 histocompatibility gene. However, Park in our laboratory reported that the intracranial ´growth of Ehrlich carcinoma did not show any necrotic area in the tumor growth till the " mouse was killed after inoculation (2 weeks), but that in the subcutaneous transplantation of the same tumor the tumor tissue showed marked necrosis even 1 week after inoculation. Ee postulated that these necroses in the tumor growth were due to the immune response of z w.Ehrlich carcinoma. The author chose the testis as a partially well protected site from the defense mechanism of the host, and also selected the kidney, liver, spleen and the pleural cavity as favorite sites for tumor inoculation.
Materials and Methods
Adult Swiss white mice each weighing about 20gm. were used for the transplantation of Ehrlich carcinoma. For the tumor transplantation 0.2c.c. tumor-saline suspension containing 3x106 tumor cells was injected respectively into the kidney, liver, spleen, testis and the pleural cavity. The implanted mice were sacrificed 1, 2, 3 weeks after the transplantation. Gross and microscopical examinations were made. ´owing
The Results were as follows :
1. The transplantation of. Ehrlich carcinoma grew in all the sites except in the spleen.
2. In all the implanted tumor growths necrosis was confirmed except in the testis one week following the tumor transplantation.

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