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Sarcoma 180 移植에서 일어나는 壤死의 宿主防禦反應과의 關係

The Significance of the Necrosis Appearing in the Implanted Sarcoma 180 Growth

현대의학 1968년 9권 4호 p.481 ~ 485
金榮澤, 金永濟,
소속 상세정보
金榮澤 (  ) - 가톨릭大學 醫學部 病理學敎室
金永濟 (  ) - 가톨릭大學 醫學部 病理學敎室

Abstract


According to de Long and" Comanl) , the kidney, liver, spleen, adrenal and the, muscle of the mouse were´ chosen for suitability test for transplantation. For the . transplantation of ;tumor tissues genetically dissimilar to the recipient, the three sitesthe testis, the brain and the anterior chamber of eyewere used experimentally because these sites seemed partially protected from the defense mechanism of the host: Therefore, it is quite natural to assume that the unique findings are commonly seen in the heterologous tumor implantation into ordinary favorite sites of immune reaction. It is generally accepted that Sarcoma 180 is not strain specific and the_´tumor has lost its inherited histocompatibility gene. Therefore, the author intented to confirm whether the Sarcoma 180 really loses its histocompatibility or not. Materials and methods:
Adult Swiss white mice each weighing about 209m were used for the transplantation of Sarcoma 180.
For the tumor transplantation 0.2c.c. tumor-saline suspension containing 3x106 tumor cells was injected respectively into the kidney, liver, spleen, testis and the pleural cavity. The implanted mice were sacrificed 1, 2, 3 weeks after the transplantation. Gross and microscopical examinations were made.
The results were as follows:
1. The transplantation of Sarcoma 180 was successful in all the sites except in the spleen.
2. In all the implanted tumor growths necrosis was confirmed except in the testis one week following the tumor transplantation.

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