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삼투질 농도와 Vasopression이 젖산생산에 미치는 영향

The influecne of on the lactic acid production by Osmotic gradients and Vasopression in the isolated kidney slices

현대의학 1969년 10권 3호 p.389 ~ 394
김창준, 강석원, 김영준, 장윤희, 안옥희, 남숙현,
소속 상세정보
김창준 (  ) - 우석대학교 의과대학 생리학교실
강석원 (  ) - 우석대학교 의과대학 생리학교실
김영준 (  ) - 우석대학교 의과대학 생리학교실
장윤희 (  ) - 우석대학교 의과대학 생리학교실
안옥희 (  ) - 우석대학교 의과대학 생리학교실
남숙현 (  ) - 우석대학교 의과대학 생리학교실

Abstract


The present experiments were designed to examine in rabbit kidney cortex and inner medulla slices, the responses to the lactic acid production to osmotic gradiants as affected by vasopressin and by adenosine-triphosphate.
The os molarity of medium was :altered by changing the concentration of NaCl in the Krebs-Ringer bicarbonate solution, and the NaCl was replaced with urea.
The data demonstrate that
1) the lactic acid production in the medulla was two times in the cortex Media. In the cortex the lactic acid production was greatest in the media of 298mOsm/kg·H₂O, whereas it showed a periodic changes in the medulla as the osmolarity increased.
2) After addition of vasopressin, the lactic acid production was decreased in the media of 298mOsm/kg·H₂O but was increased in the media of 548mOsm/kg·H₂O.
3) The lactic acid production was not influenced by addition of ATP and interrelationship between vasopressin and ATP on the lactic acid production was obscure from this experiment.

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