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Reserpine에 關한 動物腦病理組織學的 硏究 HISTOPATHILOGICAL STUDY IN THE BRAIN OF ALBINO-RAT FOLLOWING ADMINISTRATION OF RESERPINE

현대의학 1969년 10권 4호 p.465 ~ 475
김철규,
소속 상세정보
김철규 (  ) 
서울대학교 대학원 신경정신과학교실

Abstract


This is the experimental study of the histopathological findings in the brain, of albinorats after administrating with reserpine alone or with reserpine and electroshock simultaneously. These were compared with normal controls. The method of experimental groups are illustrated on Table Ⅰ.
After obtaining brain tissues from cerebral cortex, Ammon´s horn, thalamus, pons, cereb ellum and medulla oblongata, the preparations were stained with the method of Nissi, Hematoxylin-Eosin stain as well as for, the neurofibrils, myelin sheeth, macroglia, microglia and fat. Then these were arranged for the subjective quantitative morphologic analysis of tissue.
The results are as follows:
1) From the group I, administered with reserpine 0.1mg/kg/day for twelve weeks by intramuscular injection, the diffuse pathological changes were found without the existence of selected areas.
2) More severe pathological changes with subacute type were found from group Ⅱ administered with reserpine 1.0mg/kg/day for three weeks.
3) The most severe acute diffuse pathological changes .were found from group Ⅲ administered with 5.0mg/kg/day of reserpine for five days. This group had the severe diarrhea and lethargy in clinical observation.
4) Subacute-diffuse ´degenerative changes were found from group Ⅳ administered with 0.mg/kg/day of reserpine and also electroconvulsion given twice weekly for fourteen times after two weeks from the biginning of reserpine injection. There were amemia and hemorrhage of capillary in several cases and also ischemic change and focal necrotic areas in pons and subcortical area.
5) There were not any finding of fatty degenerative changes from group Ⅰ, Ⅱ, and Ⅲ stained with Sudan Ⅲ, but the proliferation of oligoglias were found in group Ⅲ.
6) The author was impressed from the finings of group I that it must be carefully concidered to treat with reserpine in clinics for the large amounts and long duration because of the harmful effect of the brain tissues.
7) There were diffuse pathological changes of the tat brain administered with reserpine, but any findings for the selective areas.
8) From the findings of the experiments established reserpine alone, the pathological changes of the rat brain might be a change derived from the primary effect from the circulatory disturbance.

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