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Effect of Sihogayonggolmoryeo-Tang on Hwa-byung: A Multicenter, Randomized, Double-Blinded, Placebo-Control Trial

동의신경정신과학회지 2020년 31권 3호 p.135 ~ 147
최우창, 이헌수, 김주연, 강위창, 박양춘, 김근우, 김종우, 정인철,
소속 상세정보
최우창 ( Choi Woo-Chang ) - Daejeon University College of Korean Medicine Department of Oriental Neuropsychiatry
이헌수 ( Lee Hun-Soo ) - Daejeon University College of Korean Medicine Department of Oriental Neuropsychiatry
김주연 ( Kim Ju-Yeon ) - Daejeon University College of Korean Medicine Department of Oriental Neuropsychiatry
강위창 ( Kang Wee-Chang ) - Daejeon University Department of Statistics
박양춘 ( Park Yang-Chun ) - Daejeon University College of Korean Medicine Department of Internal Medicine
김근우 ( Kim Geun-Woo ) - Dongguk University Bundang Oriental Hospital Department of Neuropsychiatry
김종우 ( Kim Jong-Woo ) - Kyung Hee University College of Korean Medicine Department of Neuropsychiatry
정인철 ( Jung In-Chul ) - Daejeon University College of Korean Medicine Department of Oriental Neuropsychiatry

Abstract


Objectives: Hwa-byung is a mental illness. It is also known as a Korean culture-related syndrome. In traditional Korean medicine, Sihogayonggolmoryeo-tang is used to treat Hwa-byung related neuropsychiatric symptoms. The purpose of this research was to examine the effect of Sihogayonggolmoryeo- tang on Hwa-byung.

Methods: A multicenter, randomized, double-blinded, placebo-controlled study was performed for 160 patients with Hwa-byung. Patients were divided into a Sihogayonggolmoryeo-tang group and a placebo group. Treatment period was 8 weeks. Hamilton Rating Scale for Anxiety (HAM-A), Likert scale for major symptoms of Hwa-byung, Hwa-byung Scale (HBS), Korean Beck Depression Inventory (K-BDI), Korean State-Trait Anxiety Inventory (K-STAI), Korean State-Trait Anger Expression Inventory (K-STAXI), and Korean WHO Quality of Life Scale Abbreviated Version (WHOQOL-BREF) were used to evaluate the effect of Sihogayonggolmoryeo-tang on Hwa-byung. We also used an Instrument of Pattern Identification for Hwa-Byung to evaluate different responses for six patterns of patients.

Results: Scores of all the measurements improved significantly for each group, showing no significant differences between the two groups. In the case of deficiency of both Qi and blood pattern, the Sihogayonggolmoryeo-tang group showed a significant decrease in the HAM-A score compared to the placebo group.

Conclusions: The effect of Sihogayonggolmoryeo-tang on Hwa-byung did not exceed that of the placebo. Further studies involving more elaborate pattern identification are needed.

키워드

Hwa-byung; Sihogayonggolmoryeo-tang; Clinical trial; Randomized; Placebo-control study

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