잠시만 기다려 주세요. 로딩중입니다.

ADHD 동물모델에서 가감청심연자탕의 효과에 관한 실험연구

An Experimental Study on the Effect of Chengsimyeonjatanggagam Extracts on the ADHD Animal Model

동의신경정신과학회지 2020년 31권 3호 p.149 ~ 156
오영제, 류천봉, 김만기, 홍민호, 김근우, 구병수,
소속 상세정보
오영제 ( Oh Young-Je ) - Dongguk University College of Oriental Medicine Department of Neuropsychiatry
류천봉 ( Liu Quan Feng ) - Dongguk University College of Oriental Medicine Department of Neuropsychiatry
김만기 ( Kim Man-Gi ) - Dongguk University College of Oriental Medicine Department of Neuropsychiatry
홍민호 ( Hong Min-Ho ) - Dongguk University College of Oriental Medicine Department of Neuropsychiatry
김근우 ( Kim Geun-Woo ) - Dongguk University College of Oriental Medicine Department of Neuropsychiatry
구병수 ( Koo Byung-Soo ) - Dongguk University College of Oriental Medicine Department of Neuropsychiatry

Abstract


Objectives: The purpose of this study was to experimentally assess the effects of Chengsimyeonjatanggagam extracts in the animal model regarding ADHD related symptoms and indicators.

Methods: The experimental group was classified into the normal group (WKY rat) in 7, the control group (SHR rat) in 7, the low-concentration group of herbal medicines (SHR rat) in 7, and the highconcentration group of herbal medicines (SHR rat) in 7 by random sampling. The open field test was conducted three times on the 7th, 14th, and 21st days during the oral medication. After that, Y-maze test, intestinal permeability verification (L/M ratio), and Western blotting (CDK expression in the cerebral cortex) were performed in sequence.

Results: The Chengsimyeonjatang-gagam extracts reduced the activity distance in the SHR rat at 21 days in the low and high concentration groups by the open field test. It also reduced the cross-action rate in the low and high concentration groups by the Y-maze test. And the low concentration group showed 52.3% decrease in the L/M ratio compared to the SHR group. Finally, the CDK5 protein significantly increased in the low and high concentration groups.

Conclusions: This study suggests that the Chengsimyeonjatang-gagam extracts have potential to be used for the treatment of ADHD.

키워드

Herbal medicine; ADHD; Chengsimyeonjatang; Chengsimyeonjatang-gagam; L/M ratio; CDK5

원문 및 링크아웃 정보

 

등재저널 정보