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뇌졸중 후 우울증에 대한 침과 한약의 결합 치료 효과: 체계적 문헌 고찰 및 메타분석 연구

Clinical Effect of Acupuncture Combined with Herbal Medicine in Treatment of PSD: A Systematic Review and Meta-Analysis

동의신경정신과학회지 2020년 31권 3호 p.169 ~ 186
사공종원, 임수연, 김상호, 정대규,
소속 상세정보
사공종원 ( Sakong Jong-Won ) - Daegu Hanny University College of Korean Medicine Department of Oriental Neuropsychiatry
임수연 ( Lim Su-Yeon ) - Jaseng Hospital of Korean Medicine Department of Oriental Neuropsychiatry
김상호 ( Kim Sang-Ho ) - Daegu Haany University College of Korean Medicine Department of Oriental Neuropsychiatry
정대규 ( Chung Dae-Kyoo ) - Daegu Haany University College of Korean Medicine Department of Oriental Neuropsychiatry

Abstract


Objectives: The purpose of this study was to provide clinical evidence to support the use of acupuncture combined herbal medicine for post-stroke depression.

Methods: Studies were identified by searching Pubmed, EMBASE, Cochrane Library, NDSL, RISS, KMbase, KISS, and CNKI. Randomized controlled trials that verified effects of the acupuncture combined with the herbal medicine for PSD were included in this study. Literature searches of English, Chinese, and Korean databases were performed. Two authors independently extracted the data and assembled the study quality.

Results: Of 698 RCTs screened, 17 RCTs were selected. Most of the studies had unclear risk of bias. Among the 17 RCTs, 10 were meta-analyzed. As for the outcome measurement, the effective rate and the HAMD were most commonly used. The meta-analysis of the studies revealed that the PSD cure effective rate in the acupuncture combined with herbal medicine group was higher than that in the Western medicine group (RR: 1.23, 95% CI: 1.14 to 1.33, p<0.00001, I2=0%). Also, the HAMD in the acupuncture combined with herbal medicine group was significantly different compared to the Western medicine group (MD -5.54, 95% CI -9.80 to -1.29, p=0.01, I2=99%). The quality of the selected RCTs was low.
Conclusions: Acupuncture combined with herbal medicine is effective for treating post-stroke depression. However, It is worth noting that the included studies were of relatively poor quality. The sample sizes were also small. Based on the findings of this study, further investigations into the diagnosis and treatment of PSD are warranted.

키워드

Post-stroke depression; PSD; Herbal medicine; Acupuncture; Randomized controlled trial; Meta-analysis; Systematic review

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