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HIV 핵산증폭검사 양성 헌혈 혈액의 바이러스 유전자 정량 및 유전자형 분석

Analysis of HIV RNA Genotypes and Quantitative Values of HIV NAT Reactive Blood Donations

대한수혈학회지 2020년 31권 2호 p.141 ~ 152
강정원, 강재원, 고대호, 윤미애, 권소영,
소속 상세정보
강정원 ( Kang Jung-Won ) - Korean Red Cross Korean Redcross Blood Transfusion Research Institute
강재원 ( Kang Jae-Won ) - Korean Red Cross Korean Redcross Blood Transfusion Research Institute
고대호 ( Ko Dae-Ho ) - Korean Red Cross Korean Redcross Blood Transfusion Research Institute
윤미애 ( Youn Mi-Ae ) - Korean Red Cross Korean Redcross Blood Transfusion Research Institute
권소영 ( Kwon So-Yong ) - Korean Red Cross Blood Service Headquaters

Abstract


Background: The Korean Red Cross adopted HIV NAT for blood donor screening in 2005 using a minipool assay. In June 2012, the NAT system was replaced with the individual assay. This study examined the characteristics of HIV NAT reactive blood donors to determine if there was any difference in their features between 10 years ago and later.

Methods: This study analyzed the HIV RNA quantitative values and the distribution of HIV subtypes using 118 HIV NAT positive blood donations (37 in 2007, 20 in 2008, 32 in 2017 and 29 in 2018).

Results: No significant variations of the quantitative values of HIV RNA and the distribution of HIV subtypes 10 years ago and later were observed. This study failed to produce quantitative values of three samples due to the low titer. The mean titer of HIV RNA of the remaining 115 samples were 5.14×104 IU/mL. The dominant HIV subtype of the HIV NAT reactive donors was B showing 54.2% (64/118). Approximately 5.9% (7/118) of the samples showed the HIV subtype C. Forty-seven samples (39.8%) showed the circulating recombinant form (CRF).

Conclusion: The rate of HIV subtype B in this study (54.2%) has decreased compared to the results of the past study (95.2%). Some of the cases showing CRF were identified as B in the past study because CRF3, 8, 9, 14, and 15 are recombinant forms, including subtype B.

키워드

HIV; Quantitative assay; Subtype

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