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RhD 불일치 조혈모세포이식에서의 수혈 선택

Transfusion in RhD Mismatch Hematopoietic Stem Cell Transplantation

대한수혈학회지 2020년 31권 2호 p.159 ~ 164
김대원, 김경희, 서일혜, 박필환, 안정열, 서자영,
소속 상세정보
김대원 ( Kim Dae-Won ) - Gachon University College of Medicine Gil Medical Center Department of Laboratory Medicine
김경희 ( Kim Kyung-Hee ) - Gachon University College of Medicine Gil Medical Center Department of Laboratory Medicine
서일혜 ( Seo Yiel-Hea ) - Gachon University College of Medicine Gil Medical Center Department of Laboratory Medicine
박필환 ( Park Pil-Whan ) - Gachon University College of Medicine Gil Medical Center Department of Laboratory Medicine
안정열 ( Ahn Jeong-Yeal ) - Gachon University College of Medicine Gil Medical Center Department of Laboratory Medicine
서자영 ( Seo Ja-Young ) - Gachon University College of Medicine Gil Medical Center Department of Laboratory Medicine

Abstract


In some cases, hematopoietic stem cell transplants (HSCT) show differences in the D antigen. In previous studies, there have been few cases of de novo anti-D alloimmunization, and even rarer cases of serious side effects or the outcomes. De novo anti-D alloimmunization has been reported to occur more frequently in minor D mismatch than in major D mismatch. For the RhD type of blood components, RhD-negative type is recommended in transfusion in RhD mismatch HSCT without anti-D in donors and recipients. But in situations of insufficient RhD-negative blood supply, this study suggests that the RhD type of blood components depends on the patients’ RhD type before transplantation, and it depends on the donors’ RhD type after transplantation, and an RhD-positive platelet transfusion may be available.

키워드

Hematopoietic stem cell transplantation; D antigen; Alloimmunization; Mismatch; Transfusion support

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