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A Paragonimiasis Patient with Allergic Reaction to Praziquantel and Resistance to Triclabendazole: Successful Treatment after Desensitization to Praziquantel

Korean Journal of Parasitology 2011년 49권 1호 p.73 ~ 77
경선영 ( Kyung Sun-Young ) - Gachon University Gil Medical Center Department of Medicine

조용균 ( Cho Yong-Kyun ) - Gachon University Gil Medical Center Department of Medicine
김유진 ( Kim Yu-Jin ) - Gachon University Gil Medical Center Department of Medicine
박정웅 ( Park Jeong-Woong ) - Gachon University Gil Medical Center Department of Medicine
정성환 ( Jeong Sung-Hwan ) - Gachon University Gil Medical Center Department of Medicine
이재익 ( Lee Jae-Ik ) - Gachon University Gil Medical Center Department of Thoracic Surgery
성연미 ( Sung Yon-Mi ) - Gachon University Gil Medical Center Department of Radiology
이상표 ( Lee Sang-Pyo ) - Gachon University Gil Medical Center Department of Medicine

Abstract


Paragonimiasis is an infectious disease caused by trematodes of the genus Paragonimus. This trematode can be treated successfully with praziquantel in more than 90% of the cases. Although praziquantel is generally well tolerated, anaphylactic reactions to this drug have been reported in a few cases. We report here a 46-year-old Korean female with paragonimiasis, presumed to be due to Paragonimus westermani, who displayed an allergic reaction to praziquantel and resistance to triclabendazole treatment. The patient was successfully treated with praziquantel following a rapid desensitization procedure. Desensitization to praziquantel could be considered when no alternative drugs are available.

키워드

Paragonimus; paragonimiasis; praziquantel; triclabendazole; drug allergy; desensitization
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