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Surveillance on the Vivax Malaria in Endemic Areas in the Republic of Korea Based on Molecular and Serological Analyses

Korean Journal of Parasitology 2020년 58권 6호 p.609 ~ 617
이성균, Hu Fengyue, Firdaus Egy Rahman, 박지훈, 한진희, 이상은, 신현일, 조형, 박원선, Lu Feng, 한은택,
소속 상세정보
이성균 ( Lee Seong-Kyun ) - Kangwon National University School of Medicine Department of Medical Environmental Biology and Tropical Medicine
 ( Hu Fengyue ) - Yangzhou University School of Medicine Department of Pathogenic Biology
 ( Firdaus Egy Rahman ) - Kangwon National University School of Medicine Department of Medical Environmental Biology and Tropical Medicine
박지훈 ( Park Ji-Hoon ) - Kangwon National University School of Medicine Department of Medical Environmental Biology and Tropical Medicine
한진희 ( Han Jin-Hee ) - Kangwon National University School of Medicine Department of Medical Environmental Biology and Tropical Medicine
이상은 ( Lee Sang-Eun ) - Korea Disease Control and Prevention Agency Division of Vectors and Parasitic Diseases
신현일 ( Shin Hyun-Il ) - Korea Disease Control and Prevention Agency Division of Vectors and Parasitic Diseases
조형 ( Cho Hyeong ) - Korea Disease Control and Prevention Agency Division of Vectors and Parasitic Diseases
박원선 ( Park Won-Sun ) - Kangwon National University School of Medicine Department of Physiology
 ( Lu Feng ) - Yangzhou University School of Medicine Department of Pathogenic Biology
한은택 ( Han Eun-Taek ) - Kangwon National University School of Medicine Department of Medical Environmental Biology and Tropical Medicine

Abstract


Plasmodium vivax reemerged in 1993. It has been sustained for more than 25 years and become one of the important indigenous parasitic diseases in northern and western parts of the Republic of Korea near the demilitarized zone. In particular, relapse is a significant concern for the control of malaria, as short- and long-term incubation periods vary among those infected in Korea. In this study, the prevalence of asymptomatic carriers was examined among residents of high endemic areas of vivax malaria during nonseasonal transmission of mosquitoes. Blood samples from 3 endemic regions in northwestern Korea were evaluated by microscopic examination, rapid diagnostic testing, and nested PCR to identify asymptomatic patients carrying malaria parasites in the community. However, no positive malaria case among residents of endemic areas was detected. Additionally, serological analysis was carried out to measure antibodies against 3 antigenic recombinant proteins of P. vivax, merozoite surface protein 1-19, circumsporozoite surface protein-VK210, and liver-stage antigen (PvLSA-N), by the protein array method. Interestingly, seropositivity of sera between previous exposure and samples without exposure to malaria was significantly higher using the PvLSA-N antigen than the other antigens, suggesting that PvLSA-N can be used as a serological marker to analyze the degree of exposure for malaria transmission in endemic areas. This indicates a very low asymptomatic carrier prevalence during the nonmalaria season in the endemic areas of Korea.

키워드

Plasmodium vivax; diagnosis; resident; endemic area; non-malaria season; serological marker; PvLSA

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