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Phylogenetic Positioning of a Strongyloides stercoralis Isolate Recovered from a Korean Patient and Comparison with Other Asian Isolates

Korean Journal of Parasitology 2020년 58권 6호 p.689 ~ 694
배재호, 정미진, 신동훈, 김현우, 안성호, 최준호, 유학선,
소속 상세정보
배재호 ( Bae Jae-Ho ) - Pusan National University School of Medicine Department of Biochemistry
정미진 ( Jeong Mi-Jin ) - Pusan National University School of Medicine Department of Parasitology and Tropical Medicine
신동훈 ( Shin Dong-Hoon ) - Pusan National University Yangsan Hospital Department of Pathology
김현우 ( Kim Hyun-Woo ) - Pusan National University Yangsan Hospital Department of Neurology
안성호 ( Ahn Sung-Ho ) - Pusan National University Yangsan Hospital Department of Neurology
최준호 ( Choi Jun-Ho ) - Pusan National University School of Medicine Department of Parasitology and Tropical Medicine
유학선 ( Yu Hak-Sun ) - Pusan National University School of Medicine Department of Parasitology and Tropical Medicine

Abstract


Strongyloidiasis is caused by Strongyloides stercoralis and is one of the most neglected tropical diseases in tropical and subtropical regions. Although several strongyloidiasis cases have been reported in Korea, genetic analysis of Korean isolates is still incomplete. In this study, a parasite was isolated from a 61-year-old man diagnosed with strongyloidiasis during the treatment of lymphoma on his retroperitoneal lymph node. Diffuse symmetric wall thickening from the ascending to descending colon and a nematode-infected intestine was observed following microscopic examination. Genomic DNA was isolated from a patient tissue block, and S. stercoralis was identified by PCR and sequencing (18S rDNA). In order to determine phylogenetic location of a Korean isolate (named KS1), we analyzed cox1 gene (500-bp) and compared it with that from 47 previous S. stercoralis isolates (28 human isolates and 19 canid isolates) from Asian countries. Our results showed that phylogenetic tree could clearly be divided into 5 different groups according to hosts and regions. KS1 was most closely related with the Chinese isolates in terms of genetic distance.

키워드

Strongyloides stercoralis; Strongyloidiasis; Phylogenetic

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