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Overall Prevalence and Distribution of Knockdown Resistance (kdr) Mutations in Aedes aegypti from Mandalay Region, Myanmar

Korean Journal of Parasitology 2020년 58권 6호 p.709 ~ 714
Naw Haung, Su Mya Nilar Chaw, Vo Tuan Cuong, Le Huong Giang, 강정미, 전호종, Mya Yi Yi, Myint Moe Kyaw, 이진영, 손운목, 김동수, 나병국,
소속 상세정보
 ( Naw Haung ) - Gyeongsang National University College of Medicine Department of Parasitology and Tropical Medicine
 ( Su Mya Nilar Chaw ) - Department of Medical Research Pyin Oo Lwin Branch
 ( Vo Tuan Cuong ) - Gyeongsang National University College of Medicine Department of Parasitology and Tropical Medicine
 ( Le Huong Giang ) - Gyeongsang National University College of Medicine Department of Parasitology and Tropical Medicine
강정미 ( Kang Jung-Mi ) - Gyeongsang National University College of Medicine Department of Parasitology and Tropical Medicine
전호종 ( Jun Ho-Jong ) - Inha University College of Medicine Department of Tropical Medicine
 ( Mya Yi Yi ) - Department of Medical Research Pyin Oo Lwin Branch
 ( Myint Moe Kyaw ) - Department of Medical Research Pyin Oo Lwin Branch
이진영 ( Lee Jin-Young ) - Inha University College of Medicine Department of Tropical Medicine
손운목 ( Sohn Woon-Mok ) - Gyeongsang National University College of Medicine Department of Parasitology and Tropical Medicine
김동수 ( Kim Tong-Soo ) - Inha University College of Medicine Department of Tropical Medicine
나병국 ( Na Byoung-Kuk ) - Gyeongsang National University College of Medicine Department of Parasitology and Tropical Medicine

Abstract


Knockdown resistance (kdr) mutations in the voltage-gated sodium channel (VGSC) of mosquitoes confer resistance to insecticides. Although insecticide resistance has been suspected to be widespread in the natural population of Aedes aegypti in Myanmar, only limited information is currently available. The overall prevalence and distribution of kdr mutations was analyzed in Ae. aegypti from Mandalay areas, Myanmar. Sequence analysis of the VGSC in Ae. aegypti from Myanmar revealed amino acid mutations at 13 and 11 positions in domains II and III of VGSC, respectively. High frequencies of S989P (68.6%), V1016G (73.5%), and F1534C (40.1%) were found in domains II and III. T1520I was also found, but the frequency was low (8.1%). The frequency of S989P/V1016G was high (55.0%), and the frequencies of V1016G/F1534C and S989P/V1016G/F1534C were also high at 30.1% and 23.5%, respectively. Novel mutations in domain II (L963Q, M976I, V977A, M994T, L995F, V996M/A, D998N, V999A, N1013D, and F1020S) and domain III (K1514R, Y1523H, V1529A, F1534L, F1537S, V1546A, F1551S, G1581D, and K1584R) were also identified. These results collectively suggest that high frequencies of kdr mutations were identified in Myanmar Ae. aegypti, indicating a high level of insecticide resistance.

키워드

Aedes aegypti; knockdown resistance; voltage-gated sodium channel; Myanmar

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