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Seroprevalence of Toxoplasma gondii assayed using Rapid Diagnostic Tests among Residents in Three Counties Adjacent to The Demilitarized Zone, Korea

Korean Journal of Parasitology 2021년 59권 1호 p.9 ~ 14
정지희, 이진영, 장윤경, 안성규, 박서혜, 홍성종, 이지후, 정점규, 안혜진, 남호우, 김동수, 김동재,
소속 상세정보
정지희 ( Jung Jee-Hi ) - Catholic University College of Medicine Department of Biomedicine Health Science
이진영 ( Lee Jin-Young ) - Inha University School of Medicine Department of Tropical Medicine
장윤경 ( Chang Yoon-Kyung ) - Catholic University College of Medicine Department of Parasitology
안성규 ( Ahn Seong-Kyu ) - Inha University School of Medicine Department of Tropical Medicine
박서혜 ( Park Seo-Hye ) - Inha University School of Medicine Department of Tropical Medicine
홍성종 ( Hong Sung-Jong ) - Chung-Ang University College of Medicine Department of Medical Environmental Biology
이지후 ( Lee Ji-Hoo ) - GenBody Inc.
정점규 ( Chong Chom-Kyu ) - GenBody Inc.
안혜진 ( Ahn Hye-Jin ) - Catholic University College of Medicine Department of Parasitology
남호우 ( Nam Ho-Woo ) - Catholic University College of Medicine Department of Parasitology
김동수 ( Kim Tong-Soo ) - Inha University School of Medicine Department of Tropical Medicine
김동재 ( Kim Dong-Jae ) - Catholic University College of Medicine Department of Biomedicine Health Science

Abstract


Toxoplasma gondii seroprevalence have been rapidly increasing in some parts of Korea. We analyzed prevalence of anti-Toxoplasma gondii antibodies, using a rapid diagnostic test (RDT), in the sera of 552 residents in Ganghwa-gun, 661 ones in Cheorwon-gun, and 305 ones in Goseong-gun, Korea in 2019. IgG/IgM RDT mounted with recombinant fragment of major surface antigen (SAG1), glutathione-S-transferase-linker-SAG1A, were applied to the sera. IgG seroprevalence was 28.1% in Ganghwa-gun, 19.5% in Cheorwon-gun and 35.7% in Goseong-gun. Odds ratios comparing Cheorwon vs Ganghwa was 0.63 (P=0.001) and Goesong versus Ganghwa was 1.47 (P=0.01) adjusting age and sex. Goseong had highest seroprevalence among the 3 counties both in crude rates and logistic regression. Although Cheorwon and Goseong are adjacent to the demilitarized zone (DMZ) in Korea, seroprevalence rate was much higher in Goseong. Further investigation on other DMZ-closed areas is necessary whether they have high prevalence rates compared to the other areas. T. gondii prevalence in Korea is still persists; proper health policy should be established.

키워드

Toxoplasmosis; sroprevalence; IgG; IgM; rapid diagnostic test

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