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실험적 뇌압박 및 척수압박

Experimental Compression of the Brain and Spinal Cord

고려대학교의과대학잡지 1976년 13권 1호 p.55 ~ 65
김결,
소속 상세정보
김결 (  ) - 고려대학교 의과대학 신경외과학교실

Abstract


Experimental brain and spinal cord compression was successfully produced in the rabbit by the expansion of the stalks of `laminaria´, a sea weed, which were placed in the cerebral epidural space, as well as the spinal epidural space at the level of fifth lumbar verterbra.
The experimental spinal cord compression and subsequent edema at the site of compression and its adjacent area were studied at interval of 6,12 and 24 hours´ compression by measuring wet weight and dry weight, and by calculating per cent water content, swelling per cent and change of water content to that in control group.
The oxygen consumption of the cerebral and cord tissues at the site of compression and its distal adjacent area of the spinal cord was investigated by using Warburg´s manometric apparatus supplying 100% oxygen.
In the normal rabbit, the average water content of the spinal cord was 63.380.9%.
The percentage of water and swelling of the cord tissues in the experimental group were higher than those in the control during the period of 24 hours´ compression, and at the site of compression they showed a tendency of rapid increase in value at an early stage, and the area adjacent to the compression demonstated values increasing gradually during the process of compression.
In control group, the average value of oxygen consumption of the cord tissue was 0.480.011O2 /mg (dry weight) /30min and those of the brain tissue were 3.440.121O2/mg (dry weight) /30min and 0.720.0410t/mg (dry weight) /30 min in the gray and white matters respectively.
The values of oxygen consumption of both cerebral gray and white matters at the site of compression were higher than in control group throughout the 24 hours´ compression, and they revealed a tendency of rather rapid increase at an early experimental stage, and of gradual decrease the--reafter.
It was noted that the changes of water content and oxygen consumption of the spinal cord and oxygen consumption of the brain were well influenced by the mechanical compression with laminaria´ insertion in the rabbit, resulting in cerebral and spinal cord edema and swelling.

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