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一部姙産婦靜脈血과 胎兒臍帶血中 鐵分濃度에 關한 硏究

Iron Concentration in Maternal Blood and Neonatal Cord Blood of some Seoulities

고려대학교의과대학잡지 1979년 16권 3호 p.453 ~ 457
김성자, 車喆煥,
소속 상세정보
김성자 (  ) - 고려대학교 의과대학 예방의학교실
車喆煥 (  ) - 고려대학교 의과대학 예방의학교실

Abstract


Various trace metals have been implicated in human health, for the most part though public usage. Occasionally, these substances have contaminated the life support system such as food. air, water and so on in large enough concentrations to produce acute or chronic hazard. The placenta actually facilitates the transfer of a variety of such metals, especially those in low concentration in maternal blood but essential for the rapid growth of the fetus. This is probably the most important aspect of metal exposure or malnutrition of fertile women who are to be pregnant.
However, the mechanism is still unknown how the concentration of these metals in the blood of fetus becomes diluted or concentrated in method of transferring from maternal blood through the placental barrier.
The emphasis on mechanism of placental barrier to moderate these metal transferring is exemplified by measuring concentration of iron in both the maternal and cord blood in paired samples.
Our concern has focused on 72 pregnant women admitted in some local clinics in Seoul for child-birth care. From their blood of paired samples, concentrations of iron were measured with atomic absorption spectrophotometer and the results were analysed as follows.
1. Mean blood concentration for iron in cord blood was 364.19161.81 (104-844)pg/ml which was 1.54 times higher than that in maternal bloob, 238, 81 133.10 (80-696),ug/ml showing significant statistical difference (p<0.01). The concentration in cord blood was not much less than that of a Japanese study whereas the concentration in maternal blood was much lower.
2. Regarding frequency distributions for concentration ranges of iron, 29 out of 72(40.2%) maternal blood samples belonged to 100-199pg/ml group whereas 24 out of 72 (33.3%) cord
blood samples belonged to 300-399g/ml group. The distribution curves of the above revealed to be positively skewed and quite different from normal distribution curve.
3. Significant positive correlation was found between iron concentrations of maternal blood and cord blood showing regression line of
y=0.378x+274.6 with r=0.3 (p<0.01)
if y indicates concentration in cord blood,
x in maternal blood, and
r a correlation coefficient.
Furthermore, the amount of increasement in cord blood increased as concentration in maternal blood decreased from 442pg/ml, whereas the amount of decreasement in cord blood increased as concentration in maternal blood increased from 442pg/ml.
The data showed that the placental barrier would be a dynamic organ with purposive selectivity according to concentration in maternal blood but is not a simple passive barrier concerning the iron transfer role from mother to fetus.

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