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Foamy Virus Integrase in Development of Viral Vector for Gene Therapy

Journal of Microbiology and Biotechnology 2020년 30권 9호 p.1273 ~ 1281
김진선, 이가은, 신차균,
소속 상세정보
김진선 ( Kim Jin-Sun ) - Chung-Ang University Department of Systems Biotechnology
이가은 ( Lee Ga-Eun ) - Chung-Ang University Department of Systems Biotechnology
신차균 ( Shin Cha-Gyun ) - Chung-Ang University Department of Systems Biotechnology

Abstract


Due to the broad host suitability of viral vectors and their high gene delivery capacity, many researchers are focusing on viral vector-mediated gene therapy. Among the retroviruses, foamy viruses have been considered potential gene therapy vectors because of their non-pathogenicity. To date, the prototype foamy virus is the only retrovirus that has a high-resolution structure of intasomes, nucleoprotein complexes formed by integrase, and viral DNA. The integration of viral DNA into the host chromosome is an essential step for viral vector development. This process is mediated by virally encoded integrase, which catalyzes unique chemical reactions. Additionally, recent studies on foamy virus integrase elucidated the catalytic functions of its three distinct domains and their effect on viral pathogenicity. This review focuses on recent advancements in biochemical, structural, and functional studies of foamy virus integrase for gene therapy vector research.

키워드

Foamy virus; integrase; intasome; viral vector

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