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Galectin-9 Induced by Dietary Prebiotics Regulates Immunomodulation to Reduce Atopic Dermatitis Symptoms in 1-Chloro-2,4-Dinitrobenzene (DNCB)-Treated NC/Nga Mice

Journal of Microbiology and Biotechnology 2020년 30권 9호 p.1343 ~ 1354
김정아, 김성학, 김인성, 유다윤, Kim Gwang-Il, 문양수, 김성찬, 이승호, 이상석, 윤철휘, 최인순, 조광근,
소속 상세정보
김정아 ( Kim Jeong-A. ) - Gyeongnam National University of Science and Technology Department of Animal Resources Technology
김성학 ( Kim Sung-Hak ) - Chonnam National University Department of Animal Science
김인성 ( Kim In-Sung ) - Gyeongnam National University of Science and Technology Department of Animal Resources Technology
유다윤 ( Yu Da-Yoon ) - Gyeongnam National University of Science and Technology Department of Animal Resources Technology
 ( Kim Gwang-Il ) - Gyeongnam National University of Science and Technology Department of Animal Resources Technology
문양수 ( Moon Yang-Soo ) - Gyeongnam National University of Science and Technology Department of Animal Science and Biotechnology
김성찬 ( Kim Sung-Chan ) - Hallym University College of Medicine Department of Biochemistry
이승호 ( Lee Seung-Ho ) - Incheon National University Department of Nano-Bioengineering
이상석 ( Lee Sang-Suk ) - Sunchon National University Department of Animal Science and Technology
윤철휘 ( Yun Cheol-Heui ) - Seoul National University Department of Agricultural Biotechnology
최인순 ( Choi In-Soon ) - Silla University Department of Life Sciences
조광근 ( Cho Kwang-Keun ) - Gyeongnam National University of Science and Technology Department of Animal Resources Technology

Abstract


Atopic dermatitis (AD) is a skin disorder that causes chronic itch. We investigated the inhibitory effects of a mixture of prebiotic short-chain galacto-oligosaccharides and long-chain fructooligosaccharides (scGOS/lcFOS), inulin, or β-glucan on AD development in 1-chloro-2,4- dinitrobenzene (DNCB)-treated NC/Nga mice. Mice were randomly assigned to six groups: untreated mice, AD control, positive control (DNCB-treated NC/Nga mice fed a dietary supplement of Zyrtec), and DNCB-treated NC/Nga mice fed a dietary supplement of prebiotics such as scGOS/lcFOS (T1), inulin (T2), or β-glucan (T3). The prebiotic treatment groups (T1, T2, and T3) showed suppression of AD symptoms, Th2 cell differentiation, and AD-like skin lesions induced by DNCB. In addition, prebiotic treatment also reduced the number of microorganisms such as Firmicutes, which is associated with AD symptoms, and increased the levels of Bacteroidetes and Ruminococcaceae, which are associated with alleviation of AD symptoms. Our findings demonstrate the inhibitory effects of prebiotics on AD development by improving the Th1/Th2 cytokine balance and beneficial symbiotic microorganisms in in vitro and in vivo models.

키워드

Gut microbiota; immunomodulation; prebiotics; Th1 cells; Th2 cells; Treg cells

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