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Orobol, A Derivative of Genistein, Inhibits Heat-Killed Propionibacterium acnes-Induced Inflammation in HaCaT Keratinocytes

Journal of Microbiology and Biotechnology 2020년 30권 9호 p.1379 ~ 1386
오윤실, 황환주, 양희, 김종훈, 박정한윤, 김종은, 이기원,
소속 상세정보
오윤실 ( Oh Yun-Sil ) - Seoul National University Department of Agricultural Biotechnology
황환주 ( Hwang Hwan-Ju ) - Seoul National University Department of Agricultural Biotechnology
양희 ( Yang Hee ) - Seoul National University Center for Food and Bioconvergence
김종훈 ( Kim Jong-Hun ) - Sungshin University Department of Food Science and Biotechnology
박정한윤 ( Park Jung-Han-Yoon ) - Seoul National University Department of Agricultural Biotechnology
김종은 ( Kim Jong-Eun ) - Korea National University of Transportation Department of Food Science and Technology
이기원 ( Lee Ki-Won ) - Seoul National University Department of Agricultural Biotechnology

Abstract


Acne is a chronic skin disease that typically occurs in the teens and twenties, and its symptoms vary according to age, sex, diet, and lifestyle. The condition is characterized by hyperproliferation of keratinocytes in the epidermis, sebum overproduction, excessive growth of Propionibacterium acnes, and P. acnes-induced skin inflammation. Interleukin (IL)-1α and IL-6 are predominant in the inflammatory lesions of acne vulgaris. These cytokines induce an inflammatory reaction in the skin in the presence of pathogens or stresses. Moreover, IL-1α accelerates the production of keratin 16, which is typically expressed in wounded or aberrant skin, leading to abnormalities in architecture and hyperkeratinization. Orobol (3’,4’,5,7-tetrahydroxyisoflavone) is a metabolite of genistein that inhibited the P. acnes-induced increases in IL-6 and IL-1α levels in human keratinocytes (HaCaTs) more effectively compared with salicylic acid. In addition, orobol decreased the IL-1α and IL-6 mRNA levels and inhibited the phosphorylation of inhibitor of kappa-B kinase, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha, and mitogen-activated protein kinase induced by P. acnes. Finally, the expression of Ki67 was decreased by orobol. Thus, orobol ameliorated the inflammation and hyperkeratinization induced by heat-killed P. acnes and thus has potential for use in functional foods and cosmetics.

키워드

Orobol; acne vulgaris; interleukin; inflammation; hyper-keratinization

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