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Anti-Biofilm Activity of Cell-Free Supernatant of Saccharomyces cerevisiae against Staphylococcus aureus

Journal of Microbiology and Biotechnology 2020년 30권 12호 p.1854 ~ 1861
김연진, 유환희, 박영진, 이나경, 백현동,
소속 상세정보
김연진 ( Kim Yeon-Jin ) - Konkuk University Department of Food science and Biotechnology of Animal Resources
유환희 ( Yu Hwan-Hee ) - Konkuk University Department of Food Science and Biotechnology of Animal Resources
박영진 ( Park Yeong-Jin ) - Konkuk University Department of Food science and Biotechnology of Animal Resources
이나경 ( Lee Na-Kyoung ) - Konkuk University Department of Food science and Biotechnology of Animal Resources
백현동 ( Paik Hyun-Dong ) - Konkuk University Department of Food science and Biotechnology of Animal Resources

Abstract


Staphylococcus aureus is one of the most common microorganisms and causes foodborne diseases. In particular, biofilm-forming S. aureus is more resistant to antimicrobial agents and sanitizing treatments than planktonic cells. Therefore, this study aimed to investigate the anti-biofilm effects of cell-free supernatant (CFS) of Saccharomyces cerevisiae isolated from cucumber jangajji compared to grapefruit seed extract (GSE). CFS and GSE inhibited and degraded S. aureus biofilms. The adhesion ability, auto-aggregation, and exopolysaccharide production of CFS-treated S. aureus, compared to those of the control, were significantly decreased. Moreover, biofilm-related gene expression was altered upon CFS treatment. Scanning electron microscopy images confirmed that CFS exerted anti-biofilm effects against S. aureus. Therefore, these results suggest that S. cerevisiae CFS has anti-biofilm potential against S. aureus strains.

키워드

Anti-biofilm; Saccharomyces cerevisiae; cell-free supernatant; grapefruit seed extract; Staphylococcus aureus

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