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Effects of Hahella chejuensis-Derived Prodigiosin on UV-Induced ROS Production, Inflammation and Cytotoxicity in HaCaT Human Skin Keratinocytes

Journal of Microbiology and Biotechnology 2021년 31권 3호 p.475 ~ 482
이지은, 김현주, 이상준, Lee Moo-Seung,
소속 상세정보
이지은 ( Lee Ji-Eun ) - Korea Research Institute of Bioscience and Biotechnology Environmental Diseases Research Center
김현주 ( Kim Hyun-Ju ) - Chung-Ang University Department of Systems Biotechnology
이상준 ( Lee Sang-Jun ) - Chung-Ang University Department of Systems Biotechnology
 ( Lee Moo-Seung ) - Korea Research Institute of Bioscience and Biotechnology Environmental Diseases Research Center

Abstract


Prodigiosins, which are natural tripyrrole red pigments and synthetic derivatives, reportedly have multiple biological effects mainly on various types of cancer cells. However, the effects of bacterial prodigiosin on non-cancerous HaCaT human skin keratinocytes have not been reported. Therefore, the present study aimed to investigate the functional activities of prodigiosin derived from cultures of the bacterium Hahella chejuensis in HaCaT cells. Cell viability, the cell proliferation rate, and reactive oxygen species (ROS) production in vitro were assayed following treatment of HaCaT cells with prodigiosin. Prodigiosin did not cause cytotoxicity and notably increased proliferation of HaCaT cells. Furthermore, prodigiosin reduced ultraviolet (UV) irradiation-induced ROS production and the inflammatory response in HaCaT cells. More importantly, prodigiosin reduced matrix metalloproteinase-9 expression and increased collagen synthesis in UV-irradiated HaCaT cells, demonstrating that it elicits anti-aging effects. In conclusion, our results reveal that H. chejuensis-derived prodigiosin is a potential natural product to develop functional cosmetic ingredients.

키워드

Prodigiosin; Hahella chejuensis; kratinocyte; UV irradiation

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