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리보플라빈을 가진 수용성 백금(II)착체의 합성과 항암활성 및 세포주기와의 관계

Synthesis, Anticancer Activity and Cellcycle Specificity of Water-Soluble PT(II) Complexes Containing Riboflavin

약학논문집-숙명대학교 1999년 16권 1호 p.33 ~ 49
황규자, 권영이,
소속 상세정보
황규자 ( Whang Kyu-Ja ) - 숙명여자대학교 약학대학
권영이 ( Kwon Young-Ee ) - 숙명여자대학교 약학대학

Abstract


A series of vitamine-containing PT(II) complexes of the type [Pt(Rf)(L)I, (where Rf=riboflavin, L=ethylenediamine, 1,3-propanediamine, 1,4-butanediamine) was synthesized and characterized by IR, electronic absorption, elemental analysis and FAB-Mass. The coordination sites of Rf to PT(II) ions were determined to be N(5) and 0(6) with resultant chelate ring formation. These compouds have much better water solubility (145-150mg/ml) than cisplatin has (1mg/ml). The anticancer activity of this Riboflavin-containing PT(II) series was investigated by MTT assay against mouse and human leukemia cell lines in vitro. Interaction between PT(II) complex and DNA were analyzed by flowcytometry, and showed G2/M arrest in L1210 cell line.

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