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Dexromethorphan이 마우스의 자발운동량에 미치는 영향

Effect of dextromethorphan on the spontaneous locomotor activity in mice

약학논문집-숙명대학교 1999년 16권 1호 p.65 ~ 73
표명운, 유경미,
소속 상세정보
표명운 ( Pyo Myoung-Yun ) - 숙명여자대학교 약학대학
유경미 ( Yu Kyoung-Mee ) - 숙명여자대학교 약학대학

Abstract


The effect of dextromethorphan(Dex) on the spontaneous locomotor activity in mice was investigated. After Dex was intraperitoneally adminstered with the dose of 20, 60 or 80mg/kg/day once a day for 1 day, 4 days or 7 days in female ICR mice. The spontaneous locomotor activity such as distance traveled(DT) was observed for 3.5hrs at 15 min intervals. The spontaneous locomotor activity was markedly increased and showed to be biphasic in a dose dependent manner.

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