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(S)-5-Isopropyl-N3-phenyl-2-thiohydantoin을 도입한 polystyrene resin을 이용한 amino acid enantiomer의 분리

Separation of Optical Isomers of Amino Acids on a Polystyrene Resin Containing (S)-5-isopropyl-N3-phenyl-2-thiohydantoin

약학논문집-숙명대학교 1999년 16권 1호 p.97 ~ 106
류재하,
소속 상세정보
류재하 ( Ryu Jae-Ha ) - 숙명여자대학교 약학대학

Abstract


An asymmetric resin containing copper(II) ions with (S)-5-isopropyl-N3 phenyl-2-thiohydantoin (IPTH) ligands fixed in a cross linked polystyrene matrix has been prepared for the separation of optical isomers of amino acids. Enantioselectivity and retention parameters for various amino acids on the sorbent containing IPTH have been evaluated using ligand-exchange chromatography. After treatment with copper (II) sulfate and elution with ammonia water-methanol mixtures, resolution of DL-alanine, glutamic acid, histidine, isoleucine, methionine, phenylalanine and valine is observed. The enantioselectivity of the sorbents with respect to the optical isomers of several amino acids is high enough to show the big difference of free energy (deltaDELTAGo) of diastereomeric sorption complex (250-400cal/mol) to allow their preparative separation.

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