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암세포주에 대한 chitosan의 세포독성

Cytotoxicity of chitosan on cancer cell lines

약학논문집-숙명대학교 2006년 23권 1호 p.1 ~ 5
민순홍, 표명운,
소속 상세정보
민순홍 ( Min Soon-Hong ) - 숙명여자대학교 약학대학
표명운 ( Pyo Myoung-Yun ) - 숙명여자대학교 약학대학

Abstract


We investigated the cytotoxicity of chitosan on cancer cell lines (P388, L1210, HCT-15, and SK-HepG-1) and mouse splenocytes as normal cells by MTT assay. Chitosan (37.5μg/ml, 75μg/ml, 112.5μg/ml, and 150μg/ml) showed dose-dependent cytotoxicity against the cancer cell lines. Particularly, chitosan showed lower cytotoxicity against the normal mouse splenocytes than against the cancer cell lines at high doses (112.5μg/ml and 150μg/ml). These results indicate that chitosan may selectively induce growth inhibition in cancer cell lines.

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