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Preparation of Temperature-Sensitive Liposomes Using Differential Scanning Calorimetry

약학논문집-숙명대학교 2006년 23권 1호 p.46 ~ 49
김진석,
소속 상세정보
김진석 ( Kim Jin-Seok ) - 숙명여자대학교 약학대학

Abstract


New temperature-sensative liposomes, which show a transition temperature around 41 ℃, were prepared using a differential scanning calorimetry method. Various compositions of phospholipids with or without encapsulated drug were tested and DPPC:DMPC:DSPC (4:1:1 molar ratio) liposome was found to have a transition temperature of 41 ℃ from solid gel state to liquid crystalline state, which might be useful for targeting of anticancer drugs or radio-sensitizers to the tumor or inflammation sites.

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