PPAR의 리간드로서 새로운 요소 유도체의 분자설계 및 합성
Design and Synthesis of Novel Urea Analog as a PPAR Ligand
약학논문집-숙명대학교 2006년 23권 1호 p.50 ~ 54
김윤정, 전라옥,
소속 상세정보
김윤정 ( Kim Yoon-Jung ) - 숙명여자대학교 약학대학
전라옥 ( Jeon Ra-Ok ) - 숙명여자대학교 약학대학
KMID : 0606320060230010050
Abstract
PPAR is one of the significant drug targets and activation of PPAR by several thiazolidinedione derivatives is well established. Herein bioisosteric replacement of thiazolidinedione to urea was carried out. Non-thiazolidinedione derivatives, [4-(2-carbazol-9-ylethoxy)phenyl]ureas (5,6) were designed and synthesized to obtain novel PPAR activators.
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원문 및 링크아웃 정보
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