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한국인의 고지혈증과 CETP 및 APOE 유전자다형

Hyperlipidemia in Korea and Genetic Polymorphisms Cholesteryl Ester Transfer Protein and Apolipoprotein E

약학논문집-숙명대학교 2006년 23권 1호 p.59 ~ 62
양미희, 양지연, 윤여정,
소속 상세정보
양미희 ( Yang Mi-Hi ) - 숙명여자대학교 약학대학 독성학교실
양지연 ( Yang Ji-Yeon ) - 숙명여자대학교 약학대학
윤여정 ( Yoon Yeo-Jung ) - 숙명여자대학교 약학대학

Abstract


Since 1980s, hyperlipidemia in Korea has been rapidly increased and its related cardiovascular diseases are one of the main causes of death in Korea. Thus, for effective prevention of hyperlipidemia, clarification of etiology of the hyperlipidemia in Koreans is required. In this study, we focused on polymorphims in genes, which are involved in cholesterol-transfer, and -binding, e.g. cholesteryl ester transfer protein (CETP) and apolipoprotein E (APOE). Study subjects were 257 Koreans (cases who had hyperlipidemia, LDL ≥130, N=47;controls, N=210;Men, 62%). Genetic polymorphism were determined by PCR-RFLP, and single base primer extension assays. As results, allele frequency of the CETP-Tag I B 1 was significantly higher in cases than that in controls (p<0.05). When age and BMI were controls for statistics, there was 2.3 fold increase of OR (95%CI, 1.1-5.1) for hyperlipidemia in the B1/B1 homozygotes compated to the B1/B2 hyperlipidemia. However, 2 SNPs, C112R and R158C of the APOE, or 5 haplotypes of the 2 SNPs were not associated with hyperlipidemia risk. Therefore , presence of the CETP-B1 allele has a potential of risk for Korean hyperlipidemia.

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