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도라지(Platycodon grandiflorum)의 임상적 효과에 대한 체계적 문헌 고찰

The Clinical Effects of Platycodon grandiflorum: A Systematic Review

생약학회지 2021년 52권 1호 p.1 ~ 12
정철운, 김선조, Nguyen Hoang Anh, 이은구, 김태하, 권성원, 양현옥, 양현옥, 이슬지,
소속 상세정보
정철운 ( Jung Cheol-Woon ) - Seoul National University College of Pharmacy
김선조 ( Kim Sun-Jo ) - Seoul National University College of Pharmacy
 ( Nguyen Hoang Anh ) - Seoul National University College of Pharmacy
이은구 (  ) - Seoul National University College of Pharmacy
김태하 ( Kim Tae-Ha ) - Seoul National University College of Pharmacy
권성원 ( Kwon Sung-Won ) - Seoul National University College of Pharmacy
양현옥 ( Yang Hyun-Ok ) - Korea Institute of Science and Technology Natural Products Research Center
양현옥 ( Yang Hyun-Ok ) - Korea Institute of Science and Technology Natural Products Research Center
이슬지 ( Lee Seul-Ji ) - Seoul National University College of Pharmacy

Abstract


Platycodon (Platycodon grandiflorum) is used as a food and medicinal ingredient worldwide, particularly in Northeast Asia. Although a large number of studies have been conducted to determine its medicinal efficacy, there is still a paucity of literature summarizing the clinical activity of Platycodon. In this systematic review, we aimed to summarize the clinical efficacy of Platycodon. All literature describing the clinical efficacy of Platycodon was collected from international databases, and relevant papers were carefully evaluated for eligibility. Data were extracted from the selected papers and quality evaluation was conducted in accordance with the standards provided by the National Institutes of Health (NIH), with all procedures being conducted in accordance with PRISMA 2009 checklist guidelines. After the removal of 342 papers, 644 studies were fully screened for their titles and abstracts, among which, 19 studies were finally selected for full summarization. Extraction of data indicated evidence of the effectiveness of Platycodon in the treatment of respiratory system-related diseases and cancer, and in the provision of immunity. However, we found that the quality and objectivity of evaluation, management of variable factors, sample size, and reproducibility were generally poor. Although Platycodon has shown potential antiviral, antibacterial, anticancer, and antidepressant effects, and promotion of immunity in clinical settings, it was not possible to integrate objective indicators to conduct a meta-analysis due to the lack of literature and insufficient studies. More investigations in the clinical setting should be conducted to confirm the functional effects of Platycodon.

키워드

Platycodon grandiflorum; Clinical study; Systematic review

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