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단삼 메탄올 추출물의 구강 병원성 세균에 대한 항균 및 항염증효과

Antibacterial Activity and Anti-inflammatory Effect of Methanol Extracts of Saliva miltiorrhiza Against Oral Pathogenic Bacteria

생약학회지 2021년 52권 1호 p.41 ~ 48
이정혁, 임동술, 최성숙,
소속 상세정보
이정혁 ( Lee Jung-Hyeok ) - Sahmyook University College of Pharmacy
임동술 ( Yim Dong-Sool ) - Sahmyook University College of Pharmacy
최성숙 ( Choi Sung-Sook ) - Sahmyook University College of Pharmacy

Abstract


This research was conducted to investigate the antibacterial and anti-inflammatory effects of MeOH Ex. of Salvia miltiorrhiza (MESM) against oral pathogenic bacteria. Minimum inhibitory concentration (MIC), removal effect of biofilm produced by Streptococcus mutans, effect of gene expression of proinflammatory cytokines and effect of production of proinflammatory cytokine of MESM were tested. MESM showed moderated antibacterial activity against oral pathogenic bacteria. About 89±8% of biofilms produced by S. mutans were removed by MESM at a concentration of 1 mg/mL. Gene expression of IL-1b and TNF-a induced by Porphyromonas gingivalis were 8~9 folds reduced by MESM. Gene expression of IL-8 induced by Fusobacterium nucelatum were 12 folds reduced by MESM. Production of IL-1b, TNF-a and IL-8 were significantly suppressed by MESM. Conclusively, MESM showed potent antibacterial and anti-inflammatory effect against oral pathogenic bacteria.

키워드

Anti-inflammatory effects; MeOH Ex. of Salvia miltiorrhiza; Oral pathogenic bacteria; IL-1b; TNF-a

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